Sharpe is deeply committed to the issues of child and adolescent mental health, child rights, and sexual and reproductive health and rights; she believes that they are significantly interrelated. She has written, presented and published scientific papers in child and adolescent psychiatry including the situation analysis of children in especially difficult circumstances, child abuse and neglect in the Caribbean, and on the psychosocial issues affecting children separated from their parents due to migration.
As the President of the Family Planning Association of Trinidad and Tobago, Sharpe led the organisation’s endeavours in advocating for sexual and reproductive health and rights locally. As the President of the International Planned Parenthood Federation (IPPF), and the Chair of the Governing Council for two terms during 2005–2011, she instituted the IPPF Panel on Sexual Rights, producing ‘Sexual Rights: An IPPF Declaration’. The Declaration has received considerable international recognition.